Endocrine Case Study Shirley, a 50 year old housewife, comes in complaining of progressive weight gain of 20lbs over the last year, fatigue, postural dizziness, loss of memory, slow speech, deepening of her voice, dry skin, constipation, and cold intolerance. She is concerned and wants labs to further evaluate her condition. PMH: Anxiety disorder diagnosed 1 year ago Meds: alprazolam .5 every 6 hours as needed for anxiety Allergies: None ROS: Negative except as listed above Physical Exam: General: Obese female Vitals: T 98.6F, HR 58/min and regular, BP 110/60. Head: Normocephalic Eyes: PERRLA, EOMI, puffiness noted around eyes and face Neck: Thyroid gland is non-palpable Skin/Integument: pale, cool, dry, thick skin The provider checks labs and determines Shirley has hypothyroidism. Question answers should be based on evidence found in readings and from peer-reviewed literature. At least two sources must be used and cited in APA format for each question. Only one source can be a textbook. Resources should generally be within 5 years unless you are explaining the pathophysiology of a disease or providing pertinent background information. Discussion Questions: Explain the action of thyroid hormone and how this impacts the diagnosis. Your answer should contain the impact of the thyroid hormone on functions in the body. As Thyroid Stimulation Hormone (TSH) levels rise, explain how this impacts the negative-feedback mechanism in the body. What are the roles of Thyroxine (T4) and triiodothyronine (T3) in the body?

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