Reply to this discussion post (site sources if applicable) Clinical significance and statistical significance are both important when determining evidence-based practice (EBP) projects. They both have their own importance, which makes them superior in their own way. Statistical significance help clinicians answer questions about probability in which they can accept or reject a hypothesis. The statisitical significance can only adress if there are statisitical differences between variables. Clinical significance requires clinicians to focus on significant changes within the clinical setting. Statistical significance helps clinicians determine that there is a problem by data collection, clinical significance helps determine if the intervention orquality initiative change project was successful and efficient. For my capstone project, I will use clinical significance to support positive outcomes in project by using it to determine the efficacy and efficiency of the sepsis handoff communication tool. This tool, per the EBP journal articles I have chosen for this project, shows that implementing a handoff communication tool in not only patients with a diagnosis of sepsis, severe sepsis or septic shock, but all patients, improves patient outcomes and decreases mortality. Improving nurse to nurse or nurse to physician communication decreases time away from implementing interventions. I will use the data I collected from implementing my quality initiative handoff tool to determine if it is efficient enough to be used in practice.